No Evidence of Viral Transmission following Long-Term Implantation of Agarose Encapsulated Porcine Islets in Diabetic Dogs
Identifieur interne : 001157 ( Main/Exploration ); précédent : 001156; suivant : 001158No Evidence of Viral Transmission following Long-Term Implantation of Agarose Encapsulated Porcine Islets in Diabetic Dogs
Auteurs : Lawrence S. Gazda [États-Unis] ; Horatiu V. Vinerean [États-Unis] ; Melissa A. Laramore [États-Unis] ; Richard D. Hall [États-Unis] ; Joseph W. Carraway [États-Unis] ; Barry H. Smith [États-Unis]Source :
- Journal of Diabetes Research [ 2314-6745 ] ; 2014.
Abstract
We have previously described the use of a double coated agarose-agarose porcine islet macrobead for the treatment of type I diabetes mellitus. In the current study, the long-term viral safety of macrobead implantation into pancreatectomized diabetic dogs treated with pravastatin (
Url:
DOI: 10.1155/2014/727483
PubMed: 24995342
PubMed Central: 4068064
Affiliations:
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Gazda</name><affiliation wicri:level="2"><nlm:aff id="I1">The Rogosin Institute-Xenia Division, 740 Birch Road, Xenia, OH 45385, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Rogosin Institute-Xenia Division, 740 Birch Road, Xenia, OH 45385</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I2">The Rogosin Institute, New York, NY 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Rogosin Institute, New York, NY 10021</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Vinerean, Horatiu V" sort="Vinerean, Horatiu V" uniqKey="Vinerean H" first="Horatiu V." last="Vinerean">Horatiu V. Vinerean</name><affiliation wicri:level="2"><nlm:aff id="I3">Florida International University, Miami, FL 33199, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Florida International University, Miami, FL 33199</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Laramore, Melissa A" sort="Laramore, Melissa A" uniqKey="Laramore M" first="Melissa A." last="Laramore">Melissa A. Laramore</name><affiliation wicri:level="2"><nlm:aff id="I1">The Rogosin Institute-Xenia Division, 740 Birch Road, Xenia, OH 45385, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Rogosin Institute-Xenia Division, 740 Birch Road, Xenia, OH 45385</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Hall, Richard D" sort="Hall, Richard D" uniqKey="Hall R" first="Richard D." last="Hall">Richard D. Hall</name><affiliation wicri:level="2"><nlm:aff id="I4">Bob Evans Farms, Inc., New Albany, OH 43054, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bob Evans Farms, Inc., New Albany, OH 43054</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Carraway, Joseph W" sort="Carraway, Joseph W" uniqKey="Carraway J" first="Joseph W." last="Carraway">Joseph W. Carraway</name><affiliation wicri:level="2"><nlm:aff id="I5">NAMSA, Northwood, OH 43619, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NAMSA, Northwood, OH 43619</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Smith, Barry H" sort="Smith, Barry H" uniqKey="Smith B" first="Barry H." last="Smith">Barry H. Smith</name><affiliation wicri:level="2"><nlm:aff id="I2">The Rogosin Institute, New York, NY 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Rogosin Institute, New York, NY 10021</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I6">NewYork-Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NewYork-Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Diabetes Research</title><idno type="ISSN">2314-6745</idno><idno type="eISSN">2314-6753</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We have previously described the use of a double coated agarose-agarose porcine islet macrobead for the treatment of type I diabetes mellitus. In the current study, the long-term viral safety of macrobead implantation into pancreatectomized diabetic dogs treated with pravastatin (<italic>n</italic> = 3) was assessed while 2 dogs served as nonimplanted controls. A more gradual return to preimplant insulin requirements occurred after a 2nd implant procedure (days 148, 189, and >652) when compared to a first macrobead implantation (days 9, 21, and 21) in all macrobead implanted animals. In all three implanted dogs, porcine C-peptide was detected in the blood for at least 10 days following the first implant and for at least 26 days following the second implant. C-peptide was also present in the peritoneal fluid of all three implanted dogs at 6 months after 2nd implant and in 2 of 3 dogs at necropsy. Prescreening results of islet macrobeads and culture media prior to transplantation were negative for 13 viruses. No evidence of PERV or other viral transmission was found throughout the study. This study demonstrates that the long-term (2.4 years) implantation of agarose-agarose encapsulated porcine islets is a safe procedure in a large animal model of type I diabetes mellitus.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Feng, S" uniqKey="Feng S">S Feng</name></author><author><name sortKey="Barr, M" uniqKey="Barr M">M Barr</name></author><author><name sortKey="Roberts, J" uniqKey="Roberts J">J Roberts</name></author><author><name sortKey="Oberbauer, R" uniqKey="Oberbauer R">R Oberbauer</name></author><author><name sortKey="Kaplan, B" uniqKey="Kaplan B">B Kaplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccall, M" uniqKey="Mccall M">M McCall</name></author><author><name sortKey="Shapiro, Amj" uniqKey="Shapiro A">AMJ Shapiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larsen, Jl" uniqKey="Larsen J">JL 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Gazda</name></region><name sortKey="Carraway, Joseph W" sort="Carraway, Joseph W" uniqKey="Carraway J" first="Joseph W." last="Carraway">Joseph W. Carraway</name><name sortKey="Gazda, Lawrence S" sort="Gazda, Lawrence S" uniqKey="Gazda L" first="Lawrence S." last="Gazda">Lawrence S. Gazda</name><name sortKey="Hall, Richard D" sort="Hall, Richard D" uniqKey="Hall R" first="Richard D." last="Hall">Richard D. Hall</name><name sortKey="Laramore, Melissa A" sort="Laramore, Melissa A" uniqKey="Laramore M" first="Melissa A." last="Laramore">Melissa A. Laramore</name><name sortKey="Smith, Barry H" sort="Smith, Barry H" uniqKey="Smith B" first="Barry H." last="Smith">Barry H. Smith</name><name sortKey="Smith, Barry H" sort="Smith, Barry H" uniqKey="Smith B" first="Barry H." last="Smith">Barry H. Smith</name><name sortKey="Vinerean, Horatiu V" sort="Vinerean, Horatiu V" uniqKey="Vinerean H" first="Horatiu V." last="Vinerean">Horatiu V. 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